Read e-book online A Guide to Practical Toxicology: Evaluation, Prediction, and PDF

By David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

ISBN-10: 1420043145

ISBN-13: 9781420043143

This functional, basic, and informative textual content surveys uncomplicated ideas of toxicology. it truly is a useful advisor to comparing toxicity and comparable facts, forthcoming toxicity trying out and interpretation, and knowing the ideas of possibility prediction and probability overview and management.

A consultant to useful Toxicology:

  • examines the way to overview quite a few teams of chemicals—pharmaceuticals, cosmetics, and agrochemicals
  • provides insights on toxicity choice, normality and naturality, prediction, and regulation

Two all-new chapters cover:

Read Online or Download A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition PDF

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Extra resources for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition

Example text

For instance, Eskimos tend to be able to metabolize the anti-tuberculosis drug isoniazid, faster than Egyptians and would therefore give erroneous results were they to be used as a test system to investigate safety of use in Egyptians. Finally there is no doubt that giving even small doses of an unknown chemical to humans may not be ethically acceptable. For these reasons, experiments that attempt to find new methods of investigation and to validate them for use in safety evaluation comprise one of the more important avenues of toxicological exploration.

Production of tumors at the site of administration could have been expected. 125% to a single group of Swiss mice, equivalent to approximately 5 mg/d/mouse or about 125 mg/kg/day for a 40-g mouse. There was “substantial” early mortality due to rupture of the aorta. In survivors, a proportion of the mice developed unusual tumors in the aorta—the site of the initial toxicity—diagnosed as leiomyomas or leiomyosarcomas. No dose–response information could be gained from this experiment (there was only one group); the formulation of the chemical in the drinking water did not mimic the natural occurrence of the chemical.

Food restriction in 24 A Guide to Practical Toxicology 2nd Edition rats and use of a low-protein diet produces an increase in lifespan and a reduction in the incidence of several tumors. Lipid content of diet may be important in affecting absorption of lipophilic chemicals and the fiber content of diet affects the bioavailability of toxicants by binding, and thus reducing absorption. Nutrition, as distinct from diet, is also important; anorexia or a diet low in protein can result in lower synthesis of enzymes responsible for metabolism and elimination of chemicals.

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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk, Second Edition by David Woolley, Visit Amazon's Adam Woolley Page, search results, Learn about Author Central, Adam Woolley,

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