A Handbook of Bioanalysis and Drug Metabolism - download pdf or read online

By Gary Evans

ISBN-10: 0415275199

ISBN-13: 9780415275194

Fresh years have visible a better commercial emphasis in undergraduate and postgraduate classes within the pharmaceutical and chemical sciences. in spite of the fact that, textbooks were sluggish to evolve, leaving the sphere with no text/reference that's either tutorial and sensible within the commercial atmosphere – previously. A instruction manual of Bioanalysis and Drug Metabolismis a stimulating new textual content that examines the strategies, method, and concept of bioanalysis, pharmacokinetics, and metabolism from the viewpoint of scientists with large expert adventure in drug discovery and improvement. those 3 components of analysis support drug builders to optimize the energetic part inside capability medications thereby expanding their effectiveness, and to supply safeguard and efficacy info required by means of regulators while granting a drug license. execs with vast adventure in drug discovery and improvement in addition to really expert wisdom of the person themes contributed to every bankruptcy to create a present and well-credentialed textual content. It covers issues akin to excessive functionality liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. the original commercial viewpoint is helping to enhance concept and strengthen helpful analytical and analyzing abilities. this article is a useful advisor to scholars in classes reminiscent of pharmaceutical technology, pharmacology, chemistry, body structure and toxicology, in addition to pros within the biotechnology undefined.

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Extra resources for A Handbook of Bioanalysis and Drug Metabolism

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Invest. 85, 836–842. , Bhat, G. and Pidgeon, C. (1995) Membrane partition coefficients chromatographically measured using immobilised artificial membrane surfaces. Anal. Chem. 67, 755–762. M. (1979) Carrier mediated transport of thyroid hormones through the rat blood – brain barrier: primary role of albumin bound hormone. Endocrinology 105 605–612. M. (1988) Recent advances in blood–brain barrier transport. Ann. Rev. Pharmacol. Toxicol. 28, 25–39. J. F. (1992) Hydroxylation of warfarin by human cDNAexpressed cytochrome P-450: a role for P-450 2C9 in the etiology of (S)-warfarin drug interactions.

S. (1964) Physiological transport of drugs. Adv. Drug Res. 1, 71–106. A. M. (1977) Use of distribution coefficients in quantitative structure/activity relationships. J. Med. Chem. 20, 53–58. A. M. (1979) The analysis of electronic factors in quantitative structure/ activity relationships using distribution coefficients. In: Computer-Assisted Drug Design. ACS Symposium Series, No. 112, pp. 507–526, Olson, C. E. (eds) Am. Chem. Soc. K. -J. (1982) Quantitative structure-pharmacokinetic relationships and drug design.

2003 4:07PM Physicochemical properties of drugs 21 a molecule is a key determinant of its metabolism. Lipophilicity is important, not only in terms of facilitating crossing of membranes to reach the drug-metabolising enzymes, but is also an important parameter controlling binding of the drug to the active site of the drug-metabolising enzymes. In addition to lipophilicity, the presence of ionisable groups on the molecule is also an important characteristic of compounds undergoing metabolism. Ionisable groups are important both in terms of contributing to the apparent lipophilicity of the molecule (log D) and in determining the binding to the active site of metabolising enzymes, the latter being important in dictating the regioselectivity of metabolism.

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A Handbook of Bioanalysis and Drug Metabolism by Gary Evans


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