New PDF release: Adenosine in the Nervous System

By Richard E. Stone (Auth.)

ISBN-10: 0080984193

ISBN-13: 9780080984193

ISBN-10: 012672640X

ISBN-13: 9780126726404

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And West, C A . ( 1984). Arch. Biochem. Biophys. 230, 158-67. , West, C A . L. (1987). J. Histochem. Cytochem. 35, 443-51. , K o m p , W. W. (1979). Brain Res. 168, 4 1 9 - 2 4 . , Lee, K , Reddington, M . and Kreutzberg, G. (1983). In Regulatory Function of Adenosine, eds R . M . Berne, T . W . Rail and R. Rubio. Martinus Nijhoff, T h e Hague, pp. 4 3 9 - 5 4 . Schultz, V. and Lowenstein, J . M . (1978). J. Biol. Chem. 253, 1938-43. M. (1975). J. Physiol. ) 247, 145-62. C. C. (1990). Biochem. J.

C o n s e q u e n t l y , k n o w l e d g e of t h e p h y s i o l o g i c a l significance of P p u r i n o c e p t o r s is l i m i t e d . V. Hoyle and G.

J. 214, 3 2 5 - 3 0 . , Geiger, J . D . E. and Nagy, J . I . (1987). Brain Res. Bull. 19, 4 7 3 - 8 4 . L. and Lowenstein, J . M . ( 1989). Adv. Exp. Med. Biol. 253B, 1 0 7 - 1 1 . G. and McGuffin-Clineschmidt, J . C . (1981). Eur. J. Pharmacol. 76, 137-44. V. Hoyle and Geoffrey Burnstock Department of Anatomy and Developmental Biology, and Centre for Neuroscience, University College London, Gower Street, London WC1E 6BT, UK Table of Contents Introduction P Purinoceptors in the cardiovascular system Vasoconstriction and vasodilatation Hyperaemic responses Haemostasis P Purinoceptors in the vas deferens P Purinoceptors in the urinary bladder P Purinoceptors in the gastrointestinal tract P Purinoceptors in chromatophores P Purinoceptors in peripheral ganglia Intrinsic cardiac, vesicular and myenteric ganglia Sensory ganglia P Purinoceptors and neuromodulation in the periphery Prejunctional modulation by purines Postjunctional modulation by ATP P Purinoceptors in the central nervous system Brain Spinal cord Summary References 2 2 2 2 2 2 2 2 43 48 49 52 52 53 55 58 60 60 60 61 61 62 63 64 64 66 67 68 Introduction R e s e a r c h i n t o t h e p h a r m a c o l o g y of p u r i n e c o m p o u n d s is l a r g e l y h a m p e r e d b y t h e lack of specific c o m p e t i t i v e a n t a g o n i s t s a n d of specific a g o n i s t s , w h i c h a r e n e e d e d for t h e solid c h a r a c t e r i z a t i o n of r e c e p t o r s .

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Adenosine in the Nervous System by Richard E. Stone (Auth.)


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