By Richard E. Stone (Auth.)
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C o n s e q u e n t l y , k n o w l e d g e of t h e p h y s i o l o g i c a l significance of P p u r i n o c e p t o r s is l i m i t e d . V. Hoyle and G.
J. 214, 3 2 5 - 3 0 . , Geiger, J . D . E. and Nagy, J . I . (1987). Brain Res. Bull. 19, 4 7 3 - 8 4 . L. and Lowenstein, J . M . ( 1989). Adv. Exp. Med. Biol. 253B, 1 0 7 - 1 1 . G. and McGuffin-Clineschmidt, J . C . (1981). Eur. J. Pharmacol. 76, 137-44. V. Hoyle and Geoffrey Burnstock Department of Anatomy and Developmental Biology, and Centre for Neuroscience, University College London, Gower Street, London WC1E 6BT, UK Table of Contents Introduction P Purinoceptors in the cardiovascular system Vasoconstriction and vasodilatation Hyperaemic responses Haemostasis P Purinoceptors in the vas deferens P Purinoceptors in the urinary bladder P Purinoceptors in the gastrointestinal tract P Purinoceptors in chromatophores P Purinoceptors in peripheral ganglia Intrinsic cardiac, vesicular and myenteric ganglia Sensory ganglia P Purinoceptors and neuromodulation in the periphery Prejunctional modulation by purines Postjunctional modulation by ATP P Purinoceptors in the central nervous system Brain Spinal cord Summary References 2 2 2 2 2 2 2 2 43 48 49 52 52 53 55 58 60 60 60 61 61 62 63 64 64 66 67 68 Introduction R e s e a r c h i n t o t h e p h a r m a c o l o g y of p u r i n e c o m p o u n d s is l a r g e l y h a m p e r e d b y t h e lack of specific c o m p e t i t i v e a n t a g o n i s t s a n d of specific a g o n i s t s , w h i c h a r e n e e d e d for t h e solid c h a r a c t e r i z a t i o n of r e c e p t o r s .
Adenosine in the Nervous System by Richard E. Stone (Auth.)