By Lester J. Layfield, Jonathan S. Berek (auth.), Mace L. Rothenberg (eds.)
More usually than no longer, development in medication happens incrementally. The file of an 'important' new remark is sometimes greeted through a mix of pleasure and skepticism. but the genuine price of the invention will not be identified for a number of years until eventually it truly is proven (or refuted) by way of independently carried out stories. every so often, controversy may perhaps proceed to shroud a subject matter a result of discordant effects generated by means of diverse examine teams. because the final Gynecologic Oncology quantity within the melanoma remedy and examine sequence, a few new parts have emerged that shed new gentle at the pathogenesis, prognosis, and therapy of gynecologic malignancies. during this quantity of the melanoma therapy and examine sequence, i've got tried to combine articles that spotlight a few of these most recent advancements with chapters that supply an summary of chosen components of controversy. This quantity isn't really intended to be an abbreviated textual content of gynecologic oncology yet fairly a suite of chosen works that may give you the reader with a greater viewpoint at the components of switch in the box. the applying of molecular biology to cervical melanoma has allowed us to appreciate extra thoroughly the jobs of human papilloma viruses and mobile oncogenes within the improvement of melanoma of the uterine cervix.
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Extra resources for Gynecologic Oncology: Controversies and New Developments
In its ambiguous sense, 'a few atypical squamous cells,' not otherwise specified, often confused the clinician, leaving him or her baffled as to what to do next. , recommend repeat in 3 months, 6 months, etc. ' While this is certainly desirable, it belies the point that the reason for this category is the very fact that one cannot tell what the underlying process is. However, one may often favor a benign or neoplastic origin, and this information should be communicated to the clinician. A good example of diagnostic uncertainty would be the marked squamous atypia seen in atrophic smears from some postmenopausal women, with cellular changes mimicking squamous cell carcinoma.
They also speculate that this pattern of p53 mutation may explain the apparent worse prognosis in HPV-negative tumors already discussed . Other groups, however, have been unable to confirm this pattern of results [64,65]. Further research is required to investigate this interesting association between loss of anti-oncogene function and cervical carcinogenesis. HPV as a diagnostic marker The following question arises: Can the undoubted association between HPV, particularly HPV-16, be exploited either in the prevention of cervical cancer or as a diagnostic or prognostic marker in the management of cervical cancer?
One such study (33) has investigated women with low-grade smear abnormalities by means of serial colposcopy, biopsy, and DNAIDNA hybridization, using both Southern blotting and PCR. This showed that both the histological features of virus infection and HPV-16 genome detection fluctuated with time. Furthermore, there did not appear to be a good correlation between HPV infection assessed histologically and by DNA/DNA hybridization. This fluctuation in HPV infection had also been noted in a larger study of serial smears by filter in situ hybridization (34).
Gynecologic Oncology: Controversies and New Developments by Lester J. Layfield, Jonathan S. Berek (auth.), Mace L. Rothenberg (eds.)